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differential syndrome causes rheumatology abnormal clinical coagulation prolonged pt treatment workup acquired activation algorithm blood cardiology crisis disorders essential et
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Nonspecific inhibitors e.g ... to one factor e.g ... inhibitory drugs e.g ... Nonspecific inhibitor e.g ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Pre-analytical cause (e.g ... inhibitory drugs (e.g ... specific inhibitor (e.g ... #differential #hematology
Approach to the Hypercoagulable State Arterial thromboembolism → Cardiac rhythm monitoring, Echocardiogram, Vascular imaging → Test for APS, particularly
• Provoked (e.g ... screening, CBC, aPTT ... Hypercoagulable #Workup #hematology ... #diagnosis #algorithm ... #hematology #VTE
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... PT and/or aPTT) ... #hematology #pathophysiology ... #hematology #laboratory
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Willebrand Syndrome - Diagnosis ... and Management ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... #hematology #differential
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... established disease) • aPTT ... mixing study (aPTT ... hemophilia type (e.g ... #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... cases: INR/PT, aPTT ... function test, ANA (e.g ... #Differential #Diagnosis ... Causes #Workup #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
unless worrisome EKG ... Syndrome #TLS #diagnosis ... #management #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
anterior chest wall, parts ... • A clinical diagnosis ... antiinflammatory properties e.g ... #diagnosis #management ... #Dermatology
Ventricular Fibrillation on POCUS Echocardiogram - Parasternal Short Axis 50's male witnessed arrest. Unknown hx. AED no
Fibrillation on POCUS Echocardiogram ... - Parasternal Short ... Diagnosis? ... getting 12 lead ECG ... #PSAX #POCUS #Echocardiogram
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