121 results
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Summary Acute AIDP ... Epidemiology: • 1- ... 2 cases/100,000 ... Guillain-Barre Pathophysiology ... Guillain-Barre Clinical
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... renal failure Clinical ... symptoms are not caused ... Specific sarcoidosis syndromes ... • Heerfordt syndrome
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Pathogenesis and Clinical ... Onset Alzheimer's (1% ... - Presenilin 1 ... mutations - Down syndrome ... AlzheimersDisease #Dementia #pathophysiology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... antiphospholipid syndrome ... glomerulonephritis, type 1 ... #differential #hematology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Pathogenesis and clinical ... share the same pathophysiology ... • Other rare causes ... hemianopsia IGF-1 ... Carpal Tunnel Syndrome
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
TTP/HUS, HELLP Syndrome ... Pregnancy (AFLP) Three syndromes ... coagulation defects. 1) ... child * Severe cases ... AFLP #obstetrics #hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
> 11 mg/dL / >1 ... Causes of false- ... amyloidosis Other causes ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology
Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm
Autoimmune:
 • Isolated
 • Polyglandular autoimmune syndrome 1
 •
Causes of Adrenal ... Polyglandular autoimmune syndrome ... 1 • Polyglandular ... autoimrnune syndrome ... Thrombophilia • Critical
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Anti-Synthetase Syndrome ... : Jo-1, PL7, PL12 ... Antibodies #MSAs #clinical ... #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
erythematosus 1. ... • Sjögren syndrome ... 1. ... dermatomyositis 1. ... antibodies #diagnosis #rheumatology