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diagnosis differential rheumatology management neurology erythematosus lupus signs sle systemic adhesivecapsulitis ascorbicacid barre cns complications creatine demyelinating diseases elevated frozenshoulder
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Myositis ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... Complications #pathophysiology ... #signs #symptoms
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... associated with higher CK ... greater level of muscle ... less systemic symptoms ... @AnnKumfer #Autoimmune
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Subacute to Chronic Causes ... ): • PROXIMAL MUSCLE ... myopathy - Autoimmune ... Inclusion body myositis
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... statins - probably caused
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
: • 1400 new cases ... 10-33% develop MS ... monophasic Pathophysiology ... Bilateral signs and/or symptoms ... • Infectious causes
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
associated with autoimmune ... a stroke that caused ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms ... stages #staging #msk
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
musculoskeletal symptoms ... Psychiatric symptoms ... nonimmune hemolysis MSK ... • Weakness • Muscle ... , or any other cause
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Syndrome (GBS) Acute autoimmune ... Incidence: 1 to 2 cases ... fairly symmetric muscle ... than one after symptom ... the underlying pathophysiology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Joints: myalgia and muscle ... Conjunctivitis, mucositis ... Presentation - Systemic Symptoms ... #rheumatology #classification
DEMYELINATING DISEASES OF THE CENTRAL NERVOUS SYSTEM What Are Demyelinating Diseases? • Conditions that damage myelin, the protective
Transverse Myelitis ... area postrema (nausea ... NMOSD, MOGAD, autoimmune ... /infectious causes ... MOGAD, infection, autoimmune
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