21 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Weakness, Incr CK ... Osteoporosis #Systemic ... Erythematosus #SLE #MSK ... pathophysiology #signs #symptoms
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... associated with higher CK ... greater level of muscle ... weakness, less systemic ... symptoms, and less
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Symptoms (SAMS) ... symptoms: weeks ... syndrome (GBS), systemic ... syndrome (LEMS), systemic ... Diagnosis: • CK
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
autoimmune disease ... Lupus - with Systemic ... should have other symptoms ... Amy Chung, MD, MSc ... Joint #Disorders #msk
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Joints: myalgia and muscle ... central nervous system ... diseases, such as systemic ... Presentation - Systemic ... Symptoms (Sx) in
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
Visual or auditory symptoms ... conjunction with symptoms ... central nervous system ... an underlying autoimmune ... ANCA-associated vasculitides
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
- Elevation of muscle ... Creatinine kinase (CK ... - Bilateral Muscle ... Pathophysiology #Signs #Symptoms ... #Vasculitis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
central nervous system ... Inflammatory: Vasculitis ... Peripheral Nervous System ... necrotizing myopathy • Autoimmune ... anti-Jo-1] - (Vasculitis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Symptoms (SX) in ... stiffness in proximal muscles ... shoulder and hip • Muscle ... Joints: Myalgia and muscle ... • Progressive symptoms
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... • Conduction system