13 results
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis
 • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Q fever, EBV, CMV ... Malignancy: - Hematologic ... . autoimmune): Lupus ... , Rheumatoid arthritis ... , Sarcoidosis, Adult
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
33% of healthy adults ... likely it will be clinically ... Juvenile Idiopathic Arthritis ... , Interstitial Pulmonary ... ANA #patterns #rheumatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... Fever, Arthralgia/arthritis ... HBV, Coxsackie, CMV ... hepatitis • Pulmonary
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Complex: Systemic lupus ... erythematosus, Rheumatoid arthritis ... Investigations • Labs: CBC ... , cr, ESR, CRP ... , anti-CCP • CXR
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... , adult-onset Still ... Malignancy (e.g. hematologic ... lymphoproliferative syndrome Clinical ... titers > 1:80 • CBC
Septic Arthritis - Diagnosis and Management Summary
Clinical Exam: hot, swollen, pain with passive AND active ROM
Management Summary Clinical ... necrosis, Lyme disease ... Workup: arthrocentesis ... washout • Healthy Adults ... cervical, anal Cxs
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Epidemiology: • Young adults ... association • M > F Clinical ... : Arterial (MCC-small ... Behcet syndrome (Clinical ... signs #symptoms #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
(sJIA) • Adult-onset ... • Systemic lupus ... fever syndromes Clinical ... Fever is the main clinical ... SJIA], systemic lupus
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms, Arthritis ... • Immunologic Workup ... • Immunologic Workup ... Evolution: Chronic disease
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... titer, ACE level, CXR ... ANA and RF (if clinical ... #laboratory #workup