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diagnosis management hiv neurology rheumatology associated cns dementia differential disorder hand hematology hemophagocytic hlh infections infectiousdiseases lymphohistiocytosis macrophage mas neurocognitive
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... syndromes Clinical ... is the main clinical ... 5000 to 10,000 ng/mL ... MAS #Macrophage #Activation
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
Infection in HIV / AIDS ... should be based on clinical ... • Symptoms: Fever ... • Symptoms: Fever ... differential #diagnosis #AIDS
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
impairment • Mild ... -> microglial activation ... Clinical Presentation ... : The clinical ... disorder #dementia #AIDS
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
cytokines, complement activation ... CLINICAL RECOGNITION ... in any acutely ill ... • Symptoms: Fever ... CLINICAL FEATURES
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