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diagnosis hematology hemophagocytic hlh lymphohistiocytosis pediatrics peds rheumatology treatment differential head hemeonc infant injury macrophage mas myelitis neurology sepsis septic
Step by Step Algorithmic Approach to Pediatric Fever Age < 21 days old (or 28 days for
Step by Step Algorithmic ... Age < 21 days old ... Procalcitonin >= 0.5 ng/mL ... Peds #Diagnosis #Management ... #Infant #Fever
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly ... Lymphohistiocytosis #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... syndromes Clinical ... is the main clinical ... 5000 to 10,000 ng/mL ... Syndrome #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... following: • Fever ... Ferritin >500 ng/mL ... Lymphohistiocytosis #diagnosis #management
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
cytokines, complement activation ... CLINICAL RECOGNITION ... in any acutely ill ... • Symptoms: Fever ... CLINICAL FEATURES
Algorithm for Management of Head Injuries in Children Primary survey: • Airway and cervical spine • Breathing
Algorithm for Management ... of vomiting • Clinical ... <14 if <1 year old ... bruise/swelling >5 cm ... #Algorithm #Management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Excessive activation ... Transverse Myelitis - Clinical ... - Pleocytosis: Mild ... , HIV, Hep A/B/CMV ... Myelitis #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... HLH is a critical ... by uncontrolled activation ... Clinical Presentation ... Fever b.
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