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diagnosis hematology hemophagocytic hlh lymphohistiocytosis pediatrics peds rheumatology stepbystep treatment antibiotics febrile hemeonc lp macrophage mas risk sepsis septic septicshock
Step by Step Algorithmic Approach to Pediatric Fever Age < 21 days old (or 28 days for
Step by Step Algorithmic ... Age < 21 days old ... Procalcitonin >= 0.5 ng/mL ... Peds #Diagnosis #Management ... #Infant #Fever
“Step by Step” – the new kid on the block – aims to risk stratify this
“low risk” an infant ... with fever without ... Procalcitonin <0.5 ng/mL ... #Diagnosis #Management ... Peds #Febrile #Infant
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... cytokines (TNFa,lL1, IL6 ... • Clinical: fever ... Lymphohistiocytosis #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... - Nonremitting fever ... 5000 to 10,000 ng/mL ... MAS #Macrophage #Activation ... Syndrome #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... frequently affects infants ... following: • Fever ... Ferritin >500 ng/mL ... Lymphohistiocytosis #diagnosis #management
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
cytokines, complement activation ... in any acutely ill ... • Symptoms: Fever ... INITIAL MANAGEMENT ... ADVANCED MANAGEMENT
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... by uncontrolled activation ... Onset: Usually in infancy ... Persistent high fever ... Fever b.
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