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diagnosis differential hematology activation acute agglutinin algorithm autoimmune causes chronic dyspnea emergencies hemeonc hemolytic hypoxemia hypoxia leukemia macrophage mas monoclonal
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... meningitis), MCC CNS ... collaboration • CNS ... #management #signs ... #symptoms #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... : CNS manifestations ... - infiltrates (anemia ... #Oncology #Diagnosis
Acute and Chronic Causes of Dyspnea - Differential Diagnosis Pulmonary/Chest Wall: • Acute: Trauma, COPD exacerbation, Asthma
Pulmonary/Chest Wall ... Acute: Trauma, COPD ... Tamponade • Chronic: Anemia ... hernia, Obesity CNS ... Encephalitis • Chronic: ALS
Hypoxemia / Hypoxia - Rapid Response Management Algorithm Stridor - Upper airway pathology: • Anaphylaxis • Foreign
Rapid Response Management ... asthma • Pleural disease ... Hypoventilation: • CNS ... e.g., GBS, MG, ALS ... differential #Diagnosis #Management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Scleromyxedema (CNS ... (-) hemolytic anemia ... due to cold IgG ... Differential #Diagnosis #Oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... (CAS): - Due ... • Symptoms of anemia ... hemolysis • C3↓ C4 ... #hematology #diagnosis
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS ... low Ca - q8 h TLS ... replacement Cord ... ) - Symptoms: CNS ... ) - Symptoms: CNS
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... with leukopenia, anemia ... tests ↑ AST ↑ ALT ... #Diagnosis #Management ... #Hematology #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, Elevated AST ALT ... vasculitis • Behcet ... syndrome: Recurrent ... chorioretinitis, CNS ... Differential #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... Antisynthetase syndrome ... Polymyositis or ALS ... nucleotidase 1A (Anti cN ... Myositis #Myopathy #rheumatology
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