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diagnosis differential hematology causes activation acute agglutinin algorithm autoimmune behcet chronic classification dehydrogenase dyspnea elevated emergencies extravascular hemeonc hemolysis hodgkins
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) - HELLP syndrome ... uremic syndrome ... ) (e.g. lupus, CLL ... #anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... (CAS): - Due ... anemia • Cold ... • C3↓ C4↓ • ... #hemolytic #anemia
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Scleromyxedema (CNS ... • Coombs (-) hemolytic ... anemia due to cold ... Differential #Diagnosis #Oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... : CNS manifestations ... - infiltrates (anemia ... #Oncology #Diagnosis
Acute and Chronic Causes of Dyspnea - Differential Diagnosis Pulmonary/Chest Wall: • Acute: Trauma, COPD exacerbation, Asthma
Pulmonary/Chest Wall ... Acute: Trauma, COPD ... Tamponade • Chronic: Anemia ... hernia, Obesity CNS ... Encephalitis • Chronic: ALS
Hypoxemia / Hypoxia - Rapid Response Management Algorithm Stridor - Upper airway pathology: • Anaphylaxis • Foreign
Rapid Response Management ... asthma • Pleural disease ... Hypoventilation: • CNS ... e.g., GBS, MG, ALS ... differential #Diagnosis #Management
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
, sickle cell disease ... anemia, PNH, immune ... Periodic paralyses CNS ... • Tumor lysis syndrome ... polyangiitis • Behçet's syndrome
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS ... low Ca - q8 h TLS ... replacement Cord ... ) - Symptoms: CNS ... ) - Symptoms: CNS
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... meningitis), MCC CNS ... collaboration • CNS ... #diagnosis #management ... signs #symptoms #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... with leukopenia, anemia ... tests ↑ AST ↑ ALT ... #Diagnosis #Management ... #Hematology #Rheumatology
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