26 results
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
fraction < 20% Differential ... Diaqnoses: • Infectious ... hepatitis • Pulmonary ... #diagnosis #management ... #treatment #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
basal ganglia, CNS ... ) Differential Diagnosis ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... disorder (Cardiac, pulmonary ... etc) • CNS -> ... Lack of UMN/LMN signs ... #Weakness #Differential
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Bacterial or viral infection ... Pulmonary ... Cardiomyopathies - Viral infection ... #joint #pain #differential ... #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... nervous system (CNS ... SLE], AOSD) • Infection ... #Diagnosis #Management ... #Hematology #Rheumatology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... confirm DAH, r/o infection ... #differential # ... diagnosis #management
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Eosinophilic Lung Diseases ... Hypereosinophilic Syndrome ... , wt loss; CV, CNS ... , skin • Infectious ... #pulmonary #differential
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
SLE), Sjogren's Syndrome ... Lymphoproliferative Disorders, Infection ... , Interstitial Pulmonary ... ANA #patterns #rheumatology ... #diagnosis #differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... (CAS): - Due ... to Viral infection ... younger pts) Differential ... hemolytic #anemia #hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Vasculitis Differential ... purpura: Strong sign ... chorioretinitis, CNS ... #Diagnosis #Rheumatology