11 results
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... Inclusion Body Myositis ... MithuRheum #Myositis ... #rheumatology # ... table
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Sensitive Antibodies ... Donath-Landsteiner Antibodies ... Syndrome (CAS): ... Donath-Landsteiner (IgG) antibodies ... hemolytic #anemia #hematology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... others (RNP, aPL antibodies ... Peptide (CCP) • Myositis ... #diagnosis #associations ... #table
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Necrotizing Autoimmune Myositis ... Inclusion Body Myositis ... #differential #diagnosis ... #comparison #rheumatology ... #table
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis ... of Transverse Myelitis ... that results in CNS ... Transverse Myelitis ... Antiamphiphysin antibodies
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Erythematosus - Diagnosis ... anemia 4% - Myositis ... SLE-Related Auto-Antibodies ... Differential Diagnosis ... #differential #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... Sjögren Syndrome, Myositis ... ANA #patterns #rheumatology ... #diagnosis #differential
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Parotid swelling CNS ... nervous system (CNS ... neuropathy, transverse myelitis ... • 8%-27% for CNS ... Sjogrens #Syndrome #Rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... and CNS • Headache ... • Transverse Myelitis ... #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... RP-ILD), dermato-rheumatologic ... INCLUSION BODY MYOSITIS ... lung disease • Myositis ... #Autoimmune #Myositis