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differential management disease erythematosus lupus myopathies myopathy sle systemic arthritis autoantibodies autoimmune behcet cerebritis comparison dermatology idiopathic iims laboratory myositis
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... pulmonary etc) • CNS ... spinal cord • Inflammatory ... #Differential #Diagnosis ... #neurology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Peptide (CCP) • Myositis ... Autoantibodies #Rheumatology ... #diagnosis #associations ... #table
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies ... BrighamChiefs #Inflammatory ... #differential #diagnosis ... #comparison #rheumatology ... #table
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... permeability Diagnosis ... Treatment: • Inflammatory ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
• Overlap Myositis ... that occurs in association ... Inclusion body myositis ... Myopathies #IIMs #diagnosis ... #rheumatology #
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Overview Focal inflammatory ... that results in CNS ... Diagnosis: • ... Post Vaccine • Inflammatory ... #neurology #differential
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Asia • HLA-B51 association ... Disease (25-75%): Inflammatory ... skin injury) • Neurologic ... basal ganglia, CNS ... signs #symptoms #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... level to exclude myositis ... (to support a diagnosis ... laboratory #workup #diagnosis ... #testing #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
photosensitivity, inflammatory ... Differential Diagnosis ... and CNS • Headache ... • Transverse Myelitis ... #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... affects the skin, neurologic ... chorioretinitis, CNS ... syndrome: Ocular inflammatory ... #Rheumatology
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