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rheumatology neurology management syndrome signs symptoms autoimmune behcet causes comatose compylobacterjejuni disease erythematosus extremity flaccidpalsy gbs guillainbarresyndrome headache hematology immune
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
desaturation, Scotoma, Ocular ... • Transverse myelitis ... pain • Extra-CNS ... autoimmune disorders (Systemic ... Manifestations #diagnosis
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Diagnosis Framework ... central nervous system ... Peripheral Nervous System ... #Diagnosis #neurology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
neuropathy) • Systemic ... Scleromyxedema (CNS ... Hypergammaglobulinemic macular ... Hematology #Monoclonal #Differential ... #Diagnosis #Oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome Systemic ... ulceration • Ocular ... basal ganglia, CNS ... meningitis), MCC CNS ... Behcet disease) Differential
Guillain–Barré syndrome (GBS) (aka: Landry–Guillain–Barré–Strohl syndrome:  Most common cause of acute flaccid paralysis  Rapidly progressive ascending paralysis & areflexia  Autonomic
sensory and motor systems ... Differential diagnosis ... Multiple Sclerosis: CNS ...  Transverse myelitis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
gland) biopsy • Ocular ... Parotid swelling CNS ... (CNS): demyelinating ... neuropathy, transverse myelitis ... • 8%-27% for CNS
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Diagnosis Framework ... Vasculitis Differential ... Diagnosis: • Systemic ... chorioretinitis, CNS
Leg Pain - Differential Diagnosis Framework Bone/Joint Causes of Leg Pain: • Fracture • Arthritis • Gout/pseudogout
Leg Pain - Differential ... Diagnosis Framework ... limb ischemia/cyanosis ... #diagnosis #lower ... extremity #msk #physicalexam
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematous, macular ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... and CNS • Headache ... • Transverse Myelitis
Headache Etiologies and Associated Spectrum of Severity of Disease by System Critical, Emergent and Non-Emergent Causes CNS, neurologic,
of Disease by System ... Non-Emergent Causes CNS ... vascular disease Ocular ... headache #causes #differential ... #diagnosis #neurology
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