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diagnosis rheumatology management neurology signs symptoms autoimmune behcet comatose compylobacterjejuni disease erythematosus extremity flaccidpalsy gbs guillainbarresyndrome hematology immune inflammatory iris
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
desaturation, Scotoma, Ocular ... Other brainstem syndromes ... • Transverse myelitis ... pain • Extra-CNS ... autoimmune disorders (Systemic
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... pulmonary etc) • CNS ... central nervous system ... Peripheral Nervous System ... #Weakness #Differential
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
clubbing Clarkson/Systemic ... neuropathy) • Systemic ... Scleromyxedema (CNS ... Hypergammaglobulinemic macular ... Hematology #Monoclonal #Differential
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... ulceration • Ocular ... basal ganglia, CNS ... meningitis), MCC CNS ... Behcet disease) Differential
Guillain–Barré syndrome (GBS) (aka: Landry–Guillain–Barré–Strohl syndrome:  Most common cause of acute flaccid paralysis  Rapidly progressive ascending paralysis & areflexia  Autonomic
Guillain–Barré syndrome ... sensory and motor systems ... Differential diagnosis ... Multiple Sclerosis: CNS ...  Transverse myelitis
Leg Pain - Differential Diagnosis Framework Bone/Joint Causes of Leg Pain: • Fracture • Arthritis • Gout/pseudogout
Leg Pain - Differential ... • Myositis/pyomyositis ... limb ischemia/cyanosis ... #Leg #pain #differential ... extremity #msk #physicalexam
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
gland) biopsy • Ocular ... Parotid swelling CNS ... (CNS): demyelinating ... neuropathy, transverse myelitis ... • 8%-27% for CNS
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Vasculitis Differential ... ulcers, cutaneous, ocular ... chorioretinitis, CNS ... : Ocular inflammatory
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Erythematous, macular ... permanent alopecia Differential ... and CNS • Headache ... • Transverse Myelitis
The Neurological Evaluation of a Comatose Patient Definition: • Coma: a state of unresponsiveness; the absence of
consciousness Differential ... • Locked-in syndrome ... reticular activating system ... • Vestibulo-ocular ... caseyalbin #PhysicalExam
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