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neurology rheumatology causes weakness cauda caudaequina compylobacterjejuni equina erythematosus extremity flaccidpalsy gbs gitelman guillainbarresyndrome hypokalemia immune inflammatory iris landrysyndrome leg
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Syringomyelia, Tetanus, Transverse ... Myelitis, Trauma ... Tumor • Motor Nerves ... Weakness #Causes #differential ... #diagnosis #neurology
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Diagnosis Framework ... pulmonary etc) • CNS ... #Weakness #Differential ... #Diagnosis #neurology
Guillain–Barré syndrome (GBS) (aka: Landry–Guillain–Barré–Strohl syndrome:  Most common cause of acute flaccid paralysis  Rapidly progressive ascending paralysis & areflexia  Autonomic
Guillain–Barré syndrome ... Differential diagnosis ... Multiple Sclerosis: CNS ... prominent cranial nerve ...  Transverse myelitis
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis ... that results in CNS ... Myelitis Diagnosis ... #Myelitis #diagnosis ... #differential
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... myelopathy, cranial nerve ... peripheral neuropathy, transverse ... myelitis • 8%- ... #Management
Leg Pain - Differential Diagnosis Framework Bone/Joint Causes of Leg Pain: • Fracture • Arthritis • Gout/pseudogout
Leg Pain - Differential ... Diagnosis Framework ... • Myositis/pyomyositis ... #diagnosis #lower ... extremity #msk #physicalexam
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
compression of nerve ... (CES) is usually ... Diagnosis: • ... myelopathy • Transverse ... myelitis • Multiple
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... and CNS • Headache ... neuropathy • Transverse ... Myelitis • Psychosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Diagnosis Framework ... Multinucleated giant cells ... muscle weakness • Nerves ... chorioretinitis, CNS
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... pleural effusions, CNS ... #Inflammatory #Syndrome ... #Differential # ... Diagnosis #Management
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