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clinical diagnosis pocus management ultrasound differential cardiology pulmonary checklist workup pharmacology anesthesiology criticalcare algorithm anesthesia echocardiogram intraoperative radiology treatment pathophysiology
NSAID Pharmacology - Amy Chung, MD, MSc @AmyChung #NSAIDs #Pharmacology #COX #Cyclooxygenase
#Pharmacology #COX
NSAID Selectivity Spectrum COX-2 Selective NSAID - Celecoxib • Increased risk for CV events • Decreased risk
Selectivity Spectrum COX ... Increased affinity for COX ... retain activity COX
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 Antiplatelet Drugs and their Actions - Amy Chung, MD, MSc @AmyChung #Antiplatelet #Medications #Pharmacology #Pathophysiology #Drugs #Agents #COX #GIIbIIIa
Drugs #Agents #COX
Mechanism of Action of Platelet Aggregation Inhibitors - COX Inhibitors - ADP Inhibitors - GP IIb/IIIa Receptor Blockers #Antiplatelet #Pharmacolgy
Inhibitors - COX
Arachidonic acid pathway and drugs which affect it. #Pharmacology #Pathophysiology #ArachidonicAcid #Pathways #COX #Prostaglandins #Prostacyclins #Leukotrienes #Synthesis **
ArachidonicAcid #Pathways #COX
NSAIDS and COX Selectivity Relative selectivity of some commonly used NSAIDs. Data shown as the logarithm of
NSAIDS and COX Selectivity ... COX-1 Selectivity ... Ibuprofen, Fenoprofen COX
Therapeutic Advantages and Disadvantages of some NSAIDs Salicylates: Aspirin, Salicylate salts, Diflunisal Acetic acids: Indomethacin, Sulindac, Tolmetin Propionic acids:
Meclofenamic acid, COX
Celecoxib. COX-2-specific NSAID, lower thrombembolic risk than rofecoxib and valdecoxib. Gabapentin - antiepileptic drug also used for
COX-2-specific NSAID
Ibuprofen. NSAID and non-selective COX-inhibitor used for the treatment of arthritis, pain, and fever. Originally discovered
non-selective COX-inhibitor
NSAID Dosing in CKD • Carboxylic Acids: Salsalate, Choline Mg trisalicylate • Acetic Acids: Indomethacin, Tolmetin,
Nabumetone • COX
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