724 results
Ivermectin. Old anti-parasitic agent making a comeback with recent headlines from in-vitro study that showed antiviral
activity against SARS-CoV ... Coronavirus #SARS-CoV ... InfectiousDiseases #CriticalCare
NSAID Pharmacology

- Amy Chung, MD, MSc @AmyChung 

#NSAIDs #Pharmacology #COX #Cyclooxygenase
#Pharmacology #COX
Simplified Vasopressors and Inotropes Comparison Chart
MAP = CO x SVR
Dobutamine - Norepinephrine - Epinephrine - Phenylephrine
Comparison Chart MAP = CO ... comparison #table #criticalcare
NSAID Selectivity Spectrum
COX-2 Selective NSAID - Celecoxib
 • Increased risk for CV events
 • Decreased risk
Selectivity Spectrum COX ... Increased affinity for COX ... retain activity COX
Vasopressors and Inotropes - Comparison Table
Activity: Alpha-1, Beta-1, Dopamine, SVR, HR, CO, BP
Phenylephrine
Vasopressin
Norepinephrine
Epinephrine
Dopamine
Dobutamine
Isoproterenol
Milrinone

- Dr. Eric Strong
Dopamine, SVR, HR, CO ... #pharmacology #criticalcare
Confirmation that central line is placed on the venous side by visualizing echogenic air bubbles in
Christian Fox @jchristianfox ... POCUS #Clinical #criticalcare
Shock Classification and Differential Diagnosis
SHOCK
 • MAP <65, SBP <90, drop in SBP > 40
 •
Distributive: • High CO ... Cardiogenic: • Low CO ... Obstructive: • Low CO ... Hypovolemic: • Low CO ... Diagnosis #Types #criticalcare
Antiplatelet Drugs and their Actions

- Amy Chung, MD, MSc
@AmyChung

#Antiplatelet #Medications #Pharmacology #Pathophysiology #Drugs #Agents #COX #GIIbIIIa
Drugs #Agents #COX
Mechanism of Action of Platelet Aggregation Inhibitors
- COX Inhibitors
- ADP Inhibitors
- GP IIb/IIIa Receptor Blockers

#Antiplatelet #Pharmacolgy
Inhibitors - COX
Shock - Differential Diagnosis Framework
MAP = CO x SVR
Hypovolemic (↓ Intravascular volume):
 • Hemorrhage, dehydration due
Framework MAP = CO ... third-spacing • ↓ CO ... arrhythmia • ↓ CO ... PE, PAH • ↓ CO ... table #comparison #criticalcare