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differential rheumatology adultonset cell dermatology disease erythematosus gammopathy gap gca giantcell globulin lupus mgus paraproteinemias plasmacytoma protein proteingap significance signs
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
cancer for which ... No evidence of anemia ... insufficiency, Anemia ... Bone lesions (CRAB ... #diagnosis #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... (-) hemolytic anemia ... ↓anion gap • CRAB ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
sudden onset of a rash ... - Rash: multiple ... , breast CA - Hematologic ... Sweet #Syndrome #diagnosis ... #dermatology #oncology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Fever, Arthralgia/arthritis ... , Skin rash ± odynophagia ... hemopathies, solid cancers ... #management #treatment ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... lymphopenia, low PLT • Anemia ... leukemia • Lung cancer ... • Cervical cancer
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic complaints- anemia ... required due to skip ... Start steroids if concern ... them, but urgent rheumatology ... #Management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... (RA, Temporal arteritis ... ovarian tumors, lung cancers ... Thalassemia, Sickle cell anemia ... #differential #diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
tissue composed of monoclonal ... percent • No CRAB ... - no anemia, hypercalcemia ... #Plasmacytoma #Oncology ... #Hematology
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