11 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
of Systemic Lupus ... Cerebrovascular Disease ... Puncture, EEG Treatment ... RheumOnePagers) #Systemic ... #rheumatology #
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... gangrenosum • Cutaneous ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... scarring • Subacute cutaneous ... Malignancy (e.g. hematologic ... involve PNS and CNS ... vein thrombosis Hematologic
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Systemic lupus ... (CNS) dysfunction ... lupus erythematosus ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Rare (SSA+ for cutaneous ... rare), Topics for cutaneous-DIL ... months to years) Systemic ... life-threatening • Treatment ... Evolution: Chronic disease
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
disease. ... Most common extra cutaneous ... ’s syndrome - Lupus ... Treatment: - Systemic ... #oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
inflammation Others: • Lupus ... aphthous ulcers, cutaneous ... lupus erythematosus ... strong sign of cutaneous ... • ANA (Suggest CTD
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome Systemic ... vasculitis) • Cutaneous ... basal ganglia, CNS ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Cutaneous larva migrans skin Rash
25 F recent Caribbean vacation, walked barefoot on sand and now with
No treatment is ... are first-line systemic ... rates of recurrent disease ... effective, and its ... University Infectious Diseases
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Central nervous system ... skin (xerosis) • Cutaneous ... Nephrogenic DI Hematologic ... Cytopenia: 2% Systemic ... Adenocarcinoma Treatment