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diagnosis management rheumatology causes differential oncology acidosis activation agglutinin anemia behcet classification coagulation cold dehydrogenase dermatology dic disseminated elevated elevation
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... develop leukostasis syndrome ... violaceous, nontender cutaneous ... • Tumor lysis syndrome ... #Hematology #Oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
vasculitis) • Cutaneous ... basal ganglia, CNS ... tears, Ischemia, Leukemia ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... (CAS): - Due ... presentation) • Cutaneous ... Hyperbilirubinemia • Elevated lactate ... hemolytic #anemia #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Most common extra cutaneous ... , breast CA - Hematologic ... - Lupus - Leukemia ... Treatment: - Systemic
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... Triglycerides • ↑ Lactate ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... cardiovascular surgery ... Lymphomas • Leukemias ... • Tumor lysis syndrome ... #LDH #Lactate
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
urine, sweat) - its ... presentations and disease ... regional ischemia, surgery ... before beginning treatment ... - Compartment syndrome
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
scarring • Subacute cutaneous ... Malignancy (e.g. hematologic ... involve PNS and CNS ... inflammation Cutaneous ... Hodgkin lymphoma and leukemia
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... involvement (2%) Cutaneous ... • Severe Liver Disease ... + Bleeding Treatment ... #management #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... skin (xerosis) • Cutaneous ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment ... #Rheumatology #
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