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diagnosis management rheumatology differential hemophagocytic hlh lymphohistiocytosis behcet classification dermatology erythematosus hemeonc lupus macrophage mas myelitis neurology oncology sjogrens sle
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... panuveitis, retinal vasculitis ... Arthritis, AS Treatment ... diagnosis #management #signs ... #symptoms #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Behçet Syndrome ... • Cogan Syndrome ... purpura: strong sign ... • ANA (Suggest CTD ... differential #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... nervous system (CNS ... Treatment: • Corticosteroids ... MAS #Macrophage #Activation ... #Management #Hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... Mucocutaneous lymph node syndrome ... • Behcet syndrome ... • Cogan syndrome ... Differential #Diagnosis #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
ANCA-associated vasculitis ... Malignancy (e.g. hematologic ... • Mesenteric vasculitis ... involve PNS and CNS ... Chronic B-cell activation
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... age, however the disease ... Diagnosis: HLH signs ... #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... ) • Cutaneous vasculitis ... Nephrogenic DI Hematologic ... : 2% Systemic Vasculitis ... Adenocarcinoma Treatment
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Episcleritis Signs ... , breast CA - Hematologic ... Leukocytoclastic vasculitis ... Treatment: - Systemic
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Excessive activation ... that results in CNS ... • Bilateral signs ... - Sjogren - Vasculitis ... Transverse Myelitis Treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... ▪ Autoimmune diseases ... Syndrome) 3. ... Presentation • Common Signs ... Diagnosis #Management #Hematology
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