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diagnosis management differential syndrome acidosis activation cerebritis classification coagulation dic disseminated elevation erythematosus fever immunecompromised immunocompromised intravascular lactate lactic lupus
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Erythematosus (SLE) Clinical ... autoantibodies that will cause ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
urine, sweat) - its ... shock/hypoxemia/Sepsis ... regional ischemia, surgery ... before beginning treatment ... syndrome - Sepsis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
history of trauma, sepsis ... organ damage Clinical ... Thromboembolism (7%) • CNS ... Treat primary cause ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... brucellosis) • Sepsis ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Differential Diagnosis Algorithm ... • Bacteremia/Septic ... jirovecii • CNS ... #Causes #Hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
salivary ducts Clinical ... Parotid swelling CNS ... nervous system (CNS ... • 8%-27% for CNS ... Sjogrens #Syndrome #Rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
the most common clinical ... Large vessels (aorta ... Antibodies to type ... affected tissue Treatment ... Polychondritis #rheumatology
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