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diagnosis differential antibiotic bloodcultures bloodstream candidemia candidiasis cardiology catheter crbsi failure fungemia guidelines idsa immune infection infections infectiousdiseases infective inflammatory
Candidemia Workup and Management - IDSA Guidelines 1) Antibiotics • Empiric: Echinocandins (e.g. micafungin) for most patients
Complications • Ocular ... week to assess ocular ... clinical concern for endocarditis ... #candida #candidiasis ... #treatment #fungal
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
therapy - Number one cause ... Fungal (Histoplasma ... patient a surgical candidate ... BloodCultures #Diagnosis #Management ... #Algorithm
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Hypercoagulable (APLAS ... Septic Emboli Cause ... insult due to vascular ... Treat underlying cause ... #diagnosis #management
Causes of Antibiotic Failure - Differential Diagnosis Framework Diagnosis: • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
Causes of Antibiotic ... bacteria: Viral, Fungal ... lines, osteo, endocarditis ... CNS, prostate, ocular
Suspected catheter-related bloodstream infection - Management Algorithm • Temperature 37.8 C • Rigors
Algorithm • Temperature ... metastatic infection (endocarditis ... pathogens (S. aureus, fungal ... patient has limited vascular ... #Algorithm #CRBSI
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
skin lesions, ocular ... Zoster flare, ocular ... unintentional weight loss, nausea ... Parvovirus B19 • Candida ... Differential #Diagnosis #Management
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
chondritis • Ocular ... hearing loss, nausea ... diseases 30% of cases ... ○ Syphilis ○ Fungal ... rheumatology #diagnosis #management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Diagnosis: • Direct fungal ... osteoarticular, pulmonary, ocular ... arthroconidia; the fungus ... arthritis, and endocarditis ... #Diagnosis #Management
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