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diagnosis differential fungal infectiousdiseases infective cardiology management table bcnie microbiology algorithm bacteria betadglucan biomarkers bloodculture bloodcultures candidemia candidiasis causes clinical
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
for Infective Endocarditis ... bacilli - Fungi (Candida ... , Aspergillus, Histoplasma ... ) - Culture negative ... #Endocarditis #
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
with Infective Endocarditis ... (IE) Has Negative ... Fungal (Histoplasma/Aspergillus ... patient a surgical candidate ... #Infective #Endocarditis
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
negative infective ... endocarditis Bartonella ... whipplei, Fungi (Aspergillus ... , Candida), Mycoplasma ... #negative #Endocarditis
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... Infective Endocarditis ... whipplei, Fungi (Aspergillus ... , Candida), Mycoplasma ... #Infective #Endocarditis
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Hypercoagulable (APLAS ... 90% of IE cases Culture ... • Coagulase-negative ... Tropheryma Whipplei • Aspergillus ... • Blood cultures
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
from Infective Endocarditis ... serology: Serial negative ... Frequent false-negative ... /serology: + (Negative ... #comparison #infective
Common Fungal Pathology • Candida - Small yeast intermingled with pseudohyphae • Aspergillosis - Septate
Pathology • Candida ... Pathology #clinical #microscopy ... #table #atlas # ... key #comparison
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
• Pathogens: Candida ... , Aspergillus ... Coccidioides - Negative ... Cryptococcus - Negative ... Galactomannan #diagnosis #comparison
Candidemia Workup and Management - IDSA Guidelines 1) Antibiotics • Empiric: Echinocandins (e.g. micafungin) for most patients
Susceptibilities, Negative ... Cultures • Length ... clinical concern for endocarditis ... Guidelines #Management #candida
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Endocarditis - Overview ... Hypercoagulable (APLAS ... aureus, Coagulase-negative ... Negative: • Bartonella ... Tropheryma Whipplei • Aspergillus
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