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endocarditis differential infectiousdiseases cardiology fungal infective microbiology bcnie betadglucan biomarkers management algorithm bacteria bloodculture bloodcultures causes cnie fungi fungus incidence
Fungal Biomarkers: Comparing Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi •
Galactomannan ... • Pathogens: Candida ... Galactomannan: ... #Galactomannan ... #diagnosis #comparison
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
bacilli - Fungi (Candida ... , Aspergillus, Histoplasma ... ) - Culture negative ... streptococci - Culture ... Bacteria #Pathogens #Diagnosis
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
Blood Cultures ... negative IE - ... Fungal (Histoplasma/Aspergillus ... patient a surgical candidate ... BloodCultures #Diagnosis
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
negative infective ... whipplei, Fungi (Aspergillus ... , Candida), Mycoplasma ... #differential #diagnosis ... #negative #Endocarditis
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Galactomannan Beta-D-Glucan ... • Pathogens: Candida ... Coccidioides - Negative ... Cryptococcus - Negative ... #diagnosis #comparison
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... whipplei, Fungi (Aspergillus ... , Candida), Mycoplasma ... BCNIE Diagnostic ... #Endocarditis #diagnosis
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... exceptions are Aspergillus ... • India ink - "Negative ... #microbiology #microscopy ... #staining #diagnosis
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Hypercoagulable (APLAS ... • Coagulase-negative ... Tropheryma Whipplei • Aspergillus ... Differential Diagnosis ... Endocarditis Diagnosis
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
and Differential Diagnosis ... Hypercoagulable (APLAS ... aureus, Coagulase-negative ... Negative: • Bartonella ... Tropheryma Whipplei • Aspergillus
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