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differential endocarditis infectiousdiseases causes infective management microbiology algorithm bloodculture bloodcultures cnie comparison fungal fungus incidence infections myocarditis pathogens staining stains
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... , these bacteria ... #differential #diagnosis ... #BCNIE #cardiology
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
bacilli - Fungi ... (Candida, Aspergillus ... bacilli - Fungi ... #Endocarditis #Bacteria ... #Pathogens #Diagnosis
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... remain negative ... (Aspergillus, Candida ... BCNIE Diagnostic ... #Endocarditis #diagnosis
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
Staphylococci (skin), Gram-negative ... : Candida spp. ... (mucosa), Aspergillus ... : Aspergillus spp ... #differential #diagnosis
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
have a fastidious bacteria ... this be a non-bacterial ... Fungal (Histoplasma/Aspergillus ... patient a surgical candidate ... BloodCultures #Diagnosis
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... exceptions are Aspergillus ... • India ink - "Negative ... #microbiology #microscopy ... #staining #diagnosis
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Hypercoagulable (APLAS ... • Coagulase-negative ... Tropheryma Whipplei • Aspergillus ... • Persistent bacteremia ... #management #cardiology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Hypercoagulable (APLAS ... Negative: • Bartonella ... Tropheryma Whipplei • Aspergillus ... • Persistent bacteremia ... #cardiology #infectiousdiseases
Causes of Myocarditis 1. Infectious Myocarditis • Bacterial - Staphylococcus, Streptococcus, Pneumococcus, Meningococcus, Gonococcus, Salmonella, Corynebacterium
Myocarditis • Bacterial ... ) • Fungal - Aspergillus ... , Blastomyces, Candida ... #differential #diagnosis ... #cardiology
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