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diagnosis endocarditis differential infectiousdiseases infective microbiology bcnie betadglucan biomarkers galactomannan algorithm bacteria bloodculture bloodcultures causes cnie fungus incidence management staining
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
bacilli - Fungi ... (Candida, Aspergillus ... Histoplasma) - Culture ... bacilli - Fungi ... Endocarditis #Bacteria #Pathogens
Fungal Biomarkers: Comparing Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi •
Fungal Biomarkers ... component of many fungi ... Candida, Aspergillus ... febrilepodcast #Fungal ... Galactomannan #diagnosis #comparison
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
Blood Cultures ... non-bacterial pathogen ... Fungal (Histoplasma ... /Aspergillus) / ... patient a surgical candidate
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... cell response to fungi ... doesn't stain most fungi ... staining #diagnosis #fungi ... #fungus #comparison
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
negative infective ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... #negative #Endocarditis ... #CNIE #BCNIE #cardiology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
component of many fungi ... • Pathogens: Candida ... Coccidioides - Negative ... closely related fungi ... Galactomannan #diagnosis #comparison
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... fastidious bacteria or fungi ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... bacteria) and 18S ( fungi
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