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diagnosis differential microbiology fungal infectiousdiseases infections infective morphology negative pathology bcnie management yeasts algorithm bacteria bloodculture bloodcultures causes clinical cnie
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
for Infective Endocarditis ... Gram-negative bacilli - Fungi ... (Candida, Aspergillus ... Histoplasma) - Culture ... streptococci - Culture
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
negative infective endocarditis ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... #negative #Endocarditis ... #CNIE #BCNIE #cardiology
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
with Infective Endocarditis ... Negative Blood Cultures ... Fungal (Histoplasma/Aspergillus ... patient a surgical candidate ... #Infective #Endocarditis
Morphology and Descriptions of Fungal Infections with Hyphae or Pseudohyphae in Tissues Yeasts with Pseudohyphae: •
Consistent with Candida ... spp. however Aspergillus ... other hyaline fungi ... with dematiaceous fungi ... septations #pathology #atlas
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Infective Endocarditis ... fastidious bacteria or fungi ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... Negative #Infective #Endocarditis
Morphology and Descriptions of Endemic Fungal Infections with Yeasts in Tissues Broad-based budding yeasts: • Description: Broad-based
Cryptococcus, and Aspergillus ... other hyaline fungi ... with dematiaceous fungi ... yeasts #fungal #fungi ... morphology #pathology #atlas
Morphology and Descriptions of Endemic Fungal Infections with Yeasts in Tissues Broad-based budding yeasts: • Description: Broad-based
Coccidioides spp, Candida ... Cryptococcus, and Aspergillus ... , Histoplasma, Candida ... pathology #clinical #atlas ... #fungi #microbiology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Hypercoagulable (APLAS ... 90% of IE cases Culture ... Tropheryma Whipplei • Aspergillus ... • Blood cultures ... diagnosis #management #cardiology
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... cell response to fungi ... doesn't stain most fungi ... exceptions are Aspergillus ... #microbiology #microscopy
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Endocarditis - Overview ... Hypercoagulable (APLAS ... Tropheryma Whipplei • Aspergillus ... #Endocarditis ... Differential #Diagnosis #cardiology
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