10 results
Microorganisms Responsible for Infective Endocarditis

Native valves:
 - Streptococcus viridans 
 - Enterococci 
 - Other streptococci
for Infective Endocarditis ... Gram-negative bacilli - Fungi ... (Candida, Aspergillus ... Histoplasma) - Culture ... streptococci - Culture
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood culture ... negative infective endocarditis ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... #negative #Endocarditis
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
with Infective Endocarditis ... Negative Blood Cultures ... Fungal (Histoplasma/Aspergillus ... patient a surgical candidate ... #Infective #Endocarditis
Morphology and Descriptions of Fungal Infections with Hyphae or Pseudohyphae in Tissues
Yeasts with Pseudohyphae: 
 •
Consistent with Candida ... spp. however Aspergillus ... other hyaline fungi ... with dematiaceous fungi ... septations #pathology #atlas
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Infective Endocarditis ... fastidious bacteria or fungi ... Tropheryma whipplei, Fungi ... (Aspergillus, Candida ... Negative #Infective #Endocarditis
Morphology and Descriptions of Endemic Fungal Infections with Yeasts in Tissues
Broad-based budding yeasts:
 • Description: Broad-based
Cryptococcus, and Aspergillus ... other hyaline fungi ... with dematiaceous fungi ... yeasts #fungal #fungi ... morphology #pathology #atlas
Morphology and Descriptions of Endemic Fungal Infections with Yeasts in Tissues
Broad-based budding yeasts:
 • Description: Broad-based
Coccidioides spp, Candida ... Cryptococcus, and Aspergillus ... , Histoplasma, Candida ... pathology #clinical #atlas ... #fungi #microbiology
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS ... 90% of IE cases Culture ... staphylococci Culture ... Tropheryma Whipplei • Aspergillus ... • Blood cultures
Important Fungal Stains
Mycology Lab:
 • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
preparation from culture ... cell response to fungi ... doesn't stain most fungi ... exceptions are Aspergillus ... #microbiology #microscopy
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
Endocarditis - Overview ... Hypercoagulable (APLAS ... 90% of IE cases Culture ... Tropheryma Whipplei • Aspergillus ... #Endocarditis