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diagnosis pathophysiology growthhormone causes differential excess feedbackloop management overproduction pituitary signs symptoms tallstature testing treatment
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... plate fusion -> acromegaly ... rare causes of acromegaly ... overgrowth: • Carpal ... signs #symptoms #endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... - Giantism or acromegaly ... expansion (e.g. carpal ... #FeedbackLoop #endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... : • Classic Acromegaly ... paresthesias (carpal ... decade → peripheral/acral ... Diagnosis #Management #Endocrinology
Acromegaly Testing Algorithm INDICATIONS FOR TESTING: • Adults – enlarged facial or acral features, abnormal musculoskeletal growth
Acromegaly Testing ... Algorithm INDICATIONS ... enlarged facial or acral ... Growth Hormone (GH ... #diagnosis #endocrinology
Tall Stature - Differential Diagnosis Algorithm Normal Growth (BA=CA) • Familial Tall Stature • XYY Syndrome Obese BMI
Differential Diagnosis Algorithm ... Puberty Onset • GH ... Resistance • Acromegaly ... Differential #Diagnosis #Algorithm ... #endocrinology
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