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diagnosis oncology differentiation emergencies hemeonc leukemia oncologic tls tumor
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... Lysis Syndrome ... Leukostasis: • ... , dyspnea, +/- CXR ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Triggers: ATRA treatment ... common • Imaging: CXR ... #management #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
↑ Can develop leukostasis ... , hypoxia, CXR - ... & DIC • Tumor lysis ... syndrome: Develops ... #Leukemia #Hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
TLS (tumor-lysis ... syndrome): - Hematologic ... interventional radiology ... anticoagulation Leukostasis ... (~20 %) and APL
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