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diagnosis acromegaly diabetes growthhormone causes diabetic diabeticketoacidosis differential excess feedbackloop ketoacidosis management overproduction pediatrics pituitary shortstature signs symptoms testing treatment
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... expansion (e.g. carpal ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... GH excess prior ... overgrowth: • Carpal ... signs #symptoms #endocrinology ... #pathophysiology
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA) DKA is a result of an absolute or relative insulin
Pathogenesis and Pathophysiology ... of carbohydrate metabolism ... state and fat metabolism ... #Pathophysiology ... #Diabetes #Endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
paresthesias (carpal ... Hypogonad (50%) • Metabolic ... malignancy Pathophysiology ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... Cushing's Disease • GH ... CHF) • Inborn Metabolism ... Differential #Diagnosis #Algorithm ... #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... Due to neuronal metabolism ... #pathophysiology ... #endocrinology
Acromegaly Testing Algorithm INDICATIONS FOR TESTING: • Adults – enlarged facial or acral features, abnormal musculoskeletal growth
Acromegaly Testing Algorithm ... enlarged facial or acral ... Growth Hormone (GH ... Acromegaly #Testing #Algorithm ... #diagnosis #endocrinology
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