10 results
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
expansion (e.g. carpal ... metabolic abn #GrowthHormone ... #endocrinology ... #pathophysiology ... #pituitary
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... overgrowth: • Carpal ... fraction • HTN #GrowthHormone ... signs #symptoms #endocrinology ... #pathophysiology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
paresthesias (carpal ... malignancy Pathophysiology ... pseudo-acromegaly, obesity, hypothyroidism ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
Sellar / Pituitary Mass - Differential Diagnosis Algorithm
Adenoma - Primary Anterior Pituitary
 - Secreting
Sellar / Pituitary ... Primary Anterior Pituitary ... Prolactin • GH ... Hypothyroidism) ... Diagnosis #Algorithm #endocrinology
Algorithmic Approach to Hypothyroidism - Differential Diagnosis and Management Framework

Central Hypothyroidism (Secondary or tertiary) ↓TSH, ↓FT4
Algorithmic Approach to Hypothyroidism ... Framework Central Hypothyroidism ... ↓FT4 • Post-GH ... drug-induced • Pituitary ... Diagnosis #algorithm #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... Secondary hyperthyroidism ... production by the pituitary ... #endocrinology ... #pathophysiology
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... adenomas that require treatment ... following order; GH ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Hyperthyroidism Overview

Clinical Manifestation of Hyperthyroidism:
 • Fatigue
 • Weight loss
 • Heat intolerance
 • Depression, nervousness
Hyperthyroidism ... TSH-producing pituitary ... ↑ AST/ALT • Treatment ... tenderness Treatment ... #differential #endocrinology
Acromegaly Testing Algorithm
INDICATIONS FOR TESTING:
 • Adults – enlarged facial or acral features, abnormal musculoskeletal growth
enlarged facial or acral ... Growth Hormone (GH ... MRI to evaluate pituitary ... evaluation of other pituitary ... Algorithm #diagnosis #endocrinology
Short Stature - Differential Diagnosis Algorithm
Normal Variant, Normal Puberty Onset (BA = CA)
 • Familial Short
Cushing's Disease • GH ... Dwarfism) • Hypothyroidism ... Panhypopituitarism Treatment ... Diagnosis #Algorithm #endocrinology