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Antifungal Echinocandins  - Antibiotics Class Overview

Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Caspofungin 2. ... Echinocandins #Antifungal #Caspofungin
Antifungal Agents Frequently Used in Leukemia
Antibiogram:
 • Fluconazole
 • Itraconazole
 • Voriconazole
 • Posaconazole
 • Caspofungin
Posaconazole • Caspofungin
Algorithm for Evaluation and Treatment of Asymptomatic Candiduria
Evidence for disseminated candidiasis, Unstable or neutropenic patient
1. fluconazole
-800mg iv/d 2. caspofungin
Antifungal Coverage Activity Antibiogram 

Spectrum of action of systemic antifungal agents. Solid blocks represent species in
anidulafungin; CAS = caspofungin
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
anidulafungin; CAS, caspofungin
Management of Suspected and Confirmed Candida auris 

Isolate patients with suspected C auris 
 • Private
anidulafungin, caspofungin
Candida Glabrata
Species of Candida Most Commonly Isolated in Bloodstream Infections
 • Symptomatic mucosal infection is detected
echinocandin class (caspofungin
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
Echinocandin (caspofungin