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diagnosis clinical differential management algorithm causes pathophysiology hematology radiology treatment pocus pharmacology video microscopy physicalexam pathology dermatology neurology cardiology table
Infection-Related Cancers Viruses: • HPV - Cervical, anogenital, head and neck, skin cancer • HTLV-1 - Adult
HTLV-1 - Adult T-cell ... sarcoma, Merkel cell ... • Merkel cell ... polyomavirus - Merkel cell ... #oncology #differential
Checkpoint inhibitors and indications Anti CTLA-4 antibody: • Ipilimumab: Malignant melanoma, Renal cell cancer Anti-PD-1 antibody: • Nivolumab:
melanoma, Renal cell ... melanoma, Non-small cell ... cell cancer lymphoma ... cell lung cancer ... #indications #oncology
Small Cell Lung Cancer (SCLC) Staging SCLC has 2 stages: 'Limited' or 'Extensive' Limited = disease fitting into
Small Cell Lung ... Cancer (SCLC) Staging ... SmallCell #Lung #Cancer ... SCLC #Staging #oncology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Oncologic Emergencies ... HEMATOLOGIC ONCOLOGIC ... neutrophil count < 500 cells ... STRUCTURAL ONCOLOGIC ... differential #diagnosis #cancer
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... lymphocytes/Mature B cell ... Skin: - CLL cells ... or basket cells ... diagnosis #workup #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
of ALL is of B-cell ... marrow • Mature B-cell ... involvement • T-cell ... lymphoid organs When Cancer ... Leukemia #Hematology #Oncology
Retroviral Infections: Mechanisms of Oncogenesis Note: A retrovirus is an RNA virus that uses reverse transcriptase to
into the host cell ... retrovirus-associated cancers ... ); • Human T-cell ... type 1 (Adult T-cell ... pathophysiology #immunology #oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
the hematologic cancer ... marrow plasma cells ... to the plasma cell ... marrow plasma cells ... hematology #diagnosis #oncology
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
hematopoietic cell ... for 21% of all cancers ... Lymphoproliferative #Disorders #oncology
Who to test for BRCA 1/2? Female Breast Cancer: • ≤ 45-50 years at diagnosis • Triple
Female Breast Cancer ... primary breast cancers ... old • Breast cancer ... #indications #oncology ... #Breast #Cancer
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