16 results
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
Basophilia - Differential ... Myeloproliferative Disorders ... : • Chronic myeloid ... #Differential # ... Diagnosis #causes #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... eosinophilia, basophilia ... or functional neutropenia ... (Chronic Lymphocytic ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... weeks without infection ... Cytopenias: • Neutropenia ... #Chronic #Lymphocytic ... workup #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... leukemia in adults • Disorder ... PRCA, autoimmune neutropenia ... #Chronic #Lymphocytic ... Leukemia #oncology #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... , autoimmune disorder ... younger pts) Differential ... significance (MGUS), CLL ... hemolytic #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
thalassemia, S Lepore • Basophilic ... Agglutination - Cold agglutinins ... inclusions - If infection ... Consider RBC membrane disorder ... Algorithm #workup #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Thrombocytosis - Differential ... Thrombocytosis): • Acute infection ... inflammatory disorders ... myeloid leukemia (CML ... Diagnosis #Causes #hematology
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
- Differential ... Diagnosis Neonate: - Infection ... including white blood cell ... #differential # ... diagnosis #causes #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... . primary cold agglutin ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
Evaluation of Leukocytosis:
The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages.
Include
eosinophils, & basophils ... , monocytes, & lymphocytes ... myeloproliferative disorders ... Paradoxical neutropenia ... part automated differential