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diagnosis differential low cancer causes hypernatremia hypotonic pathophysiology physiologic table volume workup
Cerebral Salt Wasting vs SIADH - Pathophysiology 1) Neurological event 2) Sodium loss from tubules 3) Naturiesis →
1) Neurological ... event 2) Sodium ... #SaltWasting #SIADH ... Pathophysiology #diagnosis #nephrology ... comparison
Modified Hyponatremia Algorithm Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants Hypotonic Hyponatremia: • ADH ON (UOsm > 100):
failure, Cirrhosis, Nephrotic ... syndrome - ... OFF (UNa > 30): SIADH ... Reset osmostat, Cerebral ... #sodium #nephrology
Volume Based Approach to Hyponatremia Hypovolemic, Serum uric acid >4 • Urine Na <20: Extra-renal losses •
Renal losses, Cerebral ... uric acid <4 • SIADH ... syndrome • Urine ... #algorithm #diagnosis ... #sodium #low #nephrology
Hypernatremia Diagnosis and Workup Step 1 . Repeat the sodium concentration. Step 2. Check plasma osmolality. NORMAL PLASMA
Workup Step 1 ... Repeat the sodium ... EUVOLEMIC • SIADH ... syndrome • renal ... #Nephrology
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... +K / serum Na >1 ... Insufficiency, Cerebral ... syndrome) • ADH ... #nephrology
Hyponatremia - Differential Diagnosis Algorithm Hypovolemic - Give volume Hypervolemic (Edematous) - Look for and treat underlying cause
CHF, cirrhosis, nephrotic ... syndrome) Euvolemic ... , SSRIs) - SIADH ... #diagnosis #nephrology ... #sodium
Hyponatremia - Differential Algorithm Isotonic Hyponatremia: Hyperlipidemia, Hyperproteinemia, Recent TURP Hypotonic Hyponatremia: • Hypovolemia: Diuretics/Nephropathies, Vomiting, Diarrhea,
• Euvolemia: SIADH ... Liver Cirrhosis, Nephrotic ... Syndrome, Chronic ... diagnosis #causes #nephrology ... #sodium #low
Hyponatremia Differential Diagnosis Algorithm in Cancer UOsm ≥ 100 mOsm/kg = Urine is inappropriately concentrated for hypotonic
Diagnosis Algorithm ... capillary leak syndrome ... inappropriate • SIAD ... adrenalitis; PD-1 ... #nephrology #oncology
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