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liver aflp algorithm chronic classification cll differentiation drug fatty gastroenterology hodgkins idiosyncratic induced injury leukemia lymphocytic lymphoma mds myelodysplasia myelodysplastic
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... ongoing ↑ LFTs or symptoms ... Idiosyncratic #differential ... #Diagnosis #Management ... gastroenterology #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
: >3 symptoms, or ... initiation • Differential ... Differentiation #Syndrome #APML ... #diagnosis #management ... #hematology #oncology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
postpartum): • Initial symptoms ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... Diagnosis: Viral ... Liver #Pregnancy #hepatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... phenomenon CLL Diagnosis ... Transform to DLBCL, PML ... #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
ingestion • B symptoms ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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