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management lupus sle classification differential disease vasculitis workup arthritis criteria eularacr fungal igg4 infections infectiousdiseases laboratory mycoses phenotypes polychondritis relapsing
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Abdominal pain (20%) Renal ... #erythematosus ... signs #symptoms #diagnosis ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... , macular, patchy ... Differential Diagnosis ... APLA/LAC: • Renal ... #Diagnosis #Rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Lupus Erythematosus ... Clinical Domains ... hemolysis • Renal ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... ischemia - Skin: erythematous ... lupus erythematosus ... • Urinalysis (Renal ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... pulmonary and renal ... • Kidneys: Non-glomerular ... ischemia • Skin: Erythematous ... #Rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Related Disease Clinical ... female, asian • Systemic ... pancreas, biliary, renal ... lesions, meninges, kidneys ... workup #treatment #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
gland) biopsy • Ocular ... salivary ducts Clinical ... Distal (Type I) renal ... lubricants • Pharmacologic ... Sjogrens #Syndrome #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Gram stain and culture ... affected joint • Systemic ... lupus erythematosus ... ANA and RF (if clinical
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
the most common clinical ... chondritis • Ocular ... seronegative) • Kidneys ... Heart failure • Renal ... Polychondritis #rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... has five major clinical ... fungal stain of clinical ... the circulatory system ... osteoarticular, pulmonary, ocular
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