592 results
Immune-related adverse events (irAE) of  immune checkpoint inhibitors (ICI) 

- By Antoine Briantais 
Dr. Benjamin
irAE) of immune checkpoint ... inhibitors (ICI ... TerrierBen #irAE #ICI
Management of Immune Checkpoint Inhibitor (ICI) Induced Cardiotoxicity
Problem - Immune checkpoint inhibitors (ICIs) are associated with
Management of Immune Checkpoint ... Inhibitor (ICI) ... Problem - Immune checkpoint ... inhibitors (ICIs ... as indicated #Checkpoint
The Cell Cycle
The cell cycle is the series of tightly regulated steps that controls cell growth
through the G1/S checkpoint ... /S, S/G2, G2/M checkpoints ... the cell cycle checkpoints ... proliferation #TF #E2F #checkpoint
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
Pathophysiology ICH ... • Spontaneous ICH ... blood volume and ICP ... if needed ICP ... High ICP: 20.
Undifferentiated shock - Algorithm for the Evaluation of Hypotension. This process for the evaluation of hypotension
halting at evaluable checkpoints
Decubitus Ulcer - Diagram of stages. A, Stage I pressure ulcer. B, Stage II pressure ulcer.
B, Stage II pressure ... C, Stage III pressure ... Ulcers #Stages #III
Myocarditis 

5 Principles of
Myocarditis:
1. Build clinical suspicion
2. Decide on EMBx
3. Manage acute cardiac injury
4. Manage chronic
anti-metabolite - Immune Checkpoint
Antiarrhythmics - Vaughan Williams Classification
Class I (Ia, Ib, Ic) - Na+ Channel Blockade
 • Slows depolarization
Class I (Ia, Ib, Ic ... complex Class II ... interval Class III
Approach to ECGs
Check
 - Age, gender, name
 - 25mm/s; 10mm/mV
 - 1mm = 40ms; 0.1 mV
Rate
(2) P+ve in l, II ... QRS +ve in I, II ... V-pacemaker, ↑K, ICD ... congenital, MI, high ICP
Antiarrhythmic Drug Classes 
IA: "Police Department Questions 
IB: Liquored Man 
IC: For Peeing, 
Ill: After Drinking
Liquored Man IC ... Lidocaine Mexiletine IC ... Propafenone III