23 results
Immune Checkpoint Inhibitors

PD-1 inhibitors
 - Nivolumab
 - Pembrolizumab
CTLA-4 inhibitors
 - Ipilimumab
 - Tremelimumab
PD-L1 inhibitors
 - Atezolizumab
Immune Checkpoint ... Durvalumab #Immune ... #Checkpoint #Inhibitors ... #Targets #Pathophysiology
Check point inhibitors and Side Effects - Immune-related adverse events (IRAEs)

What are the side effects?
 -
Side Effects - Immune-related ... - Immune-related ... to months after treatment ... - Most immune-related ... by stopping the checkpoint
Myocarditis 

5 Principles of
Myocarditis:
1. Build clinical suspicion
2. Decide on EMBx
3. Manage acute cardiac injury
4. Manage chronic
Low voltage Treatment ... anti-metabolite - Immune ... Checkpoint Inhibitors
Summary of Approach to Patients on Immune Checkpoint Inhibitors - Symptom Staging and Management for Common
to Patients on Immune ... Checkpoint Inhibitors ... Pneumonitis, Rash) #Checkpoint ... Grading #Management #Algorithm
Immune Checkpoint Inhibitor Toxicity

Main Toxicities: Colitis,  
Pneumonitis, Skin adverse events, Endocrine dysfunction, 
Hepatitis,  
Myocarditis,
Immune Checkpoint ... Complications and Treatment ... #Immune #CheckpointInhibitor
Infographic depicting the main pearls of various types of congenital adrenal hyperplasia for the medical student.
#CAH #algorithm ... diagnosis #comparison #treatment ... Endocrinology #Adrenal #pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... immunofluorescence Immune ... Goodpasture's) Pauci-immune ... differential #diagnosis #algorithm
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... Responsive to Treatment ... growth, response to treatment ... Classification #pathophysiology ... #differential #algorithm
Management of Abdominal Distension and Bloating - Treatment Algorithm

Definitions
Pathophysiology
Organic/Pathologic Etiologies:
 • Small Intestinal Bowel Overgrowth (SIBO)
and Bloating - Treatment ... Algorithm Definitions ... Pathophysiology ... Algorithm By ... #Treatment #gastroenterology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... that disrupts immune ... Others: Cellular immune ... Unknown cause Treatment ... diagnosis #management #treatment