30 results
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... ACLF) Clinical Guidelines ... Failure Infections Alcohol-Associated ... #Chronic #Liver ... Failure #Cirrhosis #Hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... > 20x normal - Acute ... 5-10x normal - Chronic ... #Patterns #Liver ... #Injury #hepatology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... ) • Advanced Liver ... Disease - Alcohol ... catastrophes, Acute ... comparison #diagnosis #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
kidney disease, Acute ... Non-megaloblastic: Alcohol ... use, Liver disease ... independent of alcohol ... diagnosis #causes #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
HEV, EBV, CMV), Alcohol-related ... dechallenge • Acute ... or chronic atypical ... e.g. ascites), Chronic ... Diagnosis #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Mixed - Check Acute ... ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... #differential #Hepatology
Alcoholic Hepatitis - Summary Overview
- Epidemiology
- Pathophysiology
- Clinical Features
- Labs
- Diagnosis
- Differential Diagnosis
- Treatment

Sarah Onorato @sonorato11

#Alcoholic
Alcoholic Hepatitis ... - Summary Overview ... Pathophysiology - Clinical ... #Hepatitis #hepatology ... diagnosis #algorithm #management
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... diagnosis #algorithm #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... headache, malaise) → Acute ... Maternal Support - Critical ... #Pregnancy #hepatology ... obgyn #diagnosis #management
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
subclinical disease to acute ... liver failure ... - Symptoms of chronic ... hepatocellular pattern of liver ... #Hepatology