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diagnosis hematology differential management myelodysplastic rheumatology activation algorithm aplastic clinical cryofibrinogenemia gangrenosum leukemia macrophage mas myelodysplasia naildisorders neutropenia pg photo
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... lines, usually painful ... • Nephrotic syndrome ... #dermatology #Differential ... Diagnosis #Algorithm #causes
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... #hematology #secondary
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... #MDS #Diagnosis ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... (MDS) (normal or ... Hypocellular/Hypoplastic MDS ... abnormalities typical for MDS ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
(MDS) What? ... DDX: Rule Out Secondary ... Causes • Anemia ... #diagnosis #hematology ... #oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
among the secondary ... underlying disease (eg ... • Infection (eg ... with leukopenia, anemia ... Diagnosis #Management #Hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cryoglobulin (CG ... sensitivity • Painful ... reticularis • Painful ... cryoglobulins • Negative causes ... Antiphospholipid syndrome
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Constitutional disorders, eg ... Chediak-Higashi syndrome ... drug reactions - Secondary ... Megaloblastic anemia-rare ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... - infiltrates (anemia ... • Tumor lysis syndrome ... bone marrow and secondary ... #Oncology #Diagnosis
Pyoderma Gangrenosum (PG) 50 M Crohn’s dz had a small pustule on the ankle 4 mo ago
worse, exquisitely painful ... corticosteroid (eg ... If v painful: Can ... cyclosporine is used PG secondary ... clinical #photo #dermatology
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