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diagnosis management cppd hematology disease hemeonc oncology pseudogout signs chondrocalcinosis comparison deposition emergencies gout hemophagocytic hlh leukemia leukostasis lymphohistiocytosis oncologic
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... changes, stroke symptoms ... Syndrome: • Pathophysiology ... diagnosis #management #hematology
Pseudogout: pathogenesis and clinical findings - Idiopathic (vast majority of cases) -> Mechanism unknown - Familial
> Clearance of calcium ... mineralization of calcium ... joint (sudden onset ... Disease #Signs #Symptoms ... #Pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
to a more rapid onset ... of symptoms. ... relatively chronic onset ... & DIC • Tumor lysis ... #Leukemia #Hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
TLS (tumor-lysis ... malignancy: - Calcium ... → treat - Calcium ... Calcitonin (rapid onset ... bisphosphonates (onset
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
4) Average age onset ... survival is 93-95% Pathophysiology ... fibrosis. 4) Calcium ... Features: • Many symptoms ... patients have no symptoms
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... precipitates with calcium ... characterized by sudden onset ... • Nocturnal onset ... Gout #Comparison #rheumatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Pseudogout Summary - Calcium ... Disease (CPPD) Pathophysiology ... precipitates with calcium ... characterized by sudden onset ... Deposition #Disease #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
- Onset: Usually ... Common Signs and Symptoms ... Pathophysiology ... Diagnosis #Management #Hematology
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