23 results
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Multi-system autoimmune disease ... myocardial fibrosis, pericarditis ... primary biliary cholangitis ... #rheumatology #diagnosis ... #signs #symptoms
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
Primary Sclerosing Cholangitis ... asymptomatic at diagnosis ... • CHOLANGITIS ... remain subject to clinical ... #diagnosis #management
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Signs and Symptoms ... but elevated as disease ... Diagnosis: • ... , IgG4 related disease ... #cholangitis #diagnosis
Constrictive Pericarditis on POCUS Echocardiogram - Apical 3-Chamber View

Young Lupus patient admitted to hospital new onset
on POCUS Echocardiogram ... you see on this SC ... Had diagnostic tap-fever ... #CP #POCUS #Echocardiogram ... #clinical #cardiology
Constrictive Pericarditis on Echocardiogram
A 55-year-old female marathon runner presents to clinic w/ 6-months of worsening breathlessness
on Echocardiogram ... runner presents to clinic ... ASA, Kussmaul's sign ... expiration not meeting diagnostic ... #a4c #pocus #clinical
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease ... in macrophages Diagnosis ... in GBA1 gene Clinical ... Neurological involvement (type ... #Diagnosis #Signs
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... >10 mmHg - clinically ... and constrictive pericarditis ... • Infiltrative diseases ... Veno-occlusive disease
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
Pathogenesis and Clinical ... other autoimmune diseases ... biliary cirrhosis (PBC ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... syndromes Heart (25%): Pericarditis ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... : Pericarditis, ... Behcet syndrome (Clinical ... ) Differential Diagnosis ... #management #signs