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endocrinology vitamind algorithm bile calcitriol causes ckd diagnosis differential hypercalcemia hyperparathyroidism management metabolism nephrology parathyroid pathophysiology pharmacology pth secondary
Vitamin D Metabolism Fat-soluble vitamin Sources: dermal synthesis and food (dairy products, fish) Active form: calcitriol (1,25-OH Vitamin D) Main
pathophysiology #Cholecalciferol
Impact and Challenges With Vitamin D to Treat Secondary Hyperparathyroidism in Patients With Chronic Kidney Disease
Ergocalciferol (D2) Cholecalciferol ... #Pharmacology #Cholecalciferol
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Calcitriol (1,25 OH Cholecalciferol ... ) - ↑ 250H Cholecalciferol ... Intake - ↓ 25OH Cholecalciferol
Light, UVB, heat Cholecalciferol vitamin D3 DBP DBP Vitamin D Pool Liver 7-Dehydro-cholesterol DBP → 25-(OH)D 1 Hydroxyl-apatite Bone Fat, bile acids Chylomicrons Vitamin D from food Skin #Parathyroid #PTH secretion Circulating 25-(OH)D DBP Kidney • 25-(OH)D 1,25-(OH,) D 1,25-(OH)w D † Ca?+-retention Metabolite #Bile
Light, UVB, heat Cholecalciferol
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