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diagnosis differential hepatology algorithm clinical causes management gastroenterology liver pocus ercp pathophysiology radiology ophthalmology ultrasound endoscopy primary signs cbd lfts
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Dysfunction - Biliary ... certain drugs, biliary ... industrial toxins) • Biliary ... Choledocholithiasis, biliary ... , carcinoma of biliary
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary Biliary
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
hepatitis, Acute biliary ... Thrombus, Vasospasm Cholestatic ... Hepatitis, TB Cholestatic ... Extrahepatic • Biliary
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Hepatocellular • Cholestatic ... on Ultrasound Biliary ... Gallstones • Biliary
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
the liver ALP - Biliary ... ALT ≥ 3x ULN Cholestatic ... pattern ≤2: Cholestatic
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
poisoning, ETOH Cholestatic ... Extrahepatic - Biliary ... Choledocholithiasis, Biliary ... - Obstruction: Biliary ... epithelia: - Cholestasis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
def, Wilson's, Cholestatic ... dz Cholestatic ... - CBD stone, Biliary
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
of Intrahepatic cholestasis ... - Pruritis - Cholestasis ... Drugs - Primary biliary ... PSC - Other biliary
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... bile ducts causes cholestasis ... No extrahepatic biliary ... , Intrahepatic cholestasis ... , Drug-induced cholestasis
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary ... inflammation and biliary ... fibrosis - Cholestasis ... #PBC #Primary #Biliary
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