1769 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
of Intrahepatic cholestasis ... - Pruritis - Cholestasis ... granulamatous disease ... - Infiltrative diseases ... Other biliary diseases
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Venoocclusive disease ... poisoning, ETOH Cholestatic ... elevation Labs in Cholestatic ... epithelia: - Cholestasis ... ALT: typical of cholestatic
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Hemochromatosis, Wilson's Disease ... Syndrome, Celiac Disease ... Thrombus, Vasospasm Cholestatic ... , Infiltrative Disease ... Hepatitis, TB Cholestatic
Unintentional Weight Loss - Differential Diagnosis Framework

Malnutrition:
 • Limited access to food
 • Anorexia
 • Disorders
• Small bowel disease ... insufficiency • Cholestatic ... liver disease
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
RNA • R < 2: Cholestasis ... Obstruction: Cholestasis ... epithelia - Cholestasis ... disease • If ... Alcoholic liver disease
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
bile ducts causes cholestasis ... but elevated as disease ... , Intrahepatic cholestasis ... , Drug-induced cholestasis ... , IgG4 related disease
Clinical Examination for Liver and Biliary Diseases
1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Liver and Biliary Diseases ... with chronic, cholestasis ... rings in Wilson's disease ... cirrhosis #liver #disease
Causes of Fat Malabsorption - Differential Diagnosis
Biliary Duct Obstruction
 • Autoimmune— PBC, PSC
 • Infection— liver
Autoimmune— Crohn's disease ... , celiac disease ... amyloidosis Other: • Cholestatic ... Autoimmune • Celiac disease ... Giardiasis • Whipple' disease
Chronic Diarrhea - Differential Diagnosis Algorithm
Steatorrhea
 - Maldigestive
    • Pancreatic Insufficiency
 - Primary
• Celiac Disease ... • Mucosal Disease ... Ileal Crohn's Disease ... Overgrowth • Liver Cholestasis ... • Whipple's Disease