2156 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary ... pathophysiology #pbc #psc #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
of Intrahepatic cholestasis ... - Pruritis - Cholestasis ... granulamatous disease ... - Infiltrative diseases ... Diagnosis #Algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Syndrome, Celiac Disease ... Thrombus, Vasospasm Cholestatic ... , Infiltrative Disease ... Hepatitis, TB Cholestatic ... Acute #algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
poisoning, ETOH Cholestatic ... elevation Labs in Cholestatic ... epithelia: - Cholestasis ... ALT: typical of cholestatic ... diagnosis #algorithm #hepatology
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
of Sickle Cell Disease ... Acute intrahepatic cholestasis ... #SickleCell #Disease ... Hepatobiliary #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
bile ducts causes cholestasis ... but elevated as disease ... , Intrahepatic cholestasis ... , IgG4 related disease ... diagnosis #workup #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
RNA • R < 2: Cholestasis ... Obstruction: Cholestasis ... disease • If ... Alcoholic liver disease ... #differential #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Others • Cholestatic ... disease US — Normal ... Others #LFTs #Hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
symptoms of liver disease ... Mixed DILI • Cholestatic ... gastroenterology #hepatology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
female-predominant disease ... of autoimmune disease ... biliary fibrosis - Cholestasis ... Pathophysiology #hepatology